Frequently Asked Questions

The First Questions Everyone Asks

It is short form for “surgical infections minimized”

S-urgical

I-nfections

MINI-mized

An infection requires two things: (a) a source – bacteria, fungus, and (b) a place to grow.  If you stop either, you stop the infection.  

Veterinary medicine exclusively manages the problem by trying to eliminate sources of infection.    The Simini Protect products are the first to address “a place to grow.”

In a clinical study of human total knee replacements with periprosthetic joint infections, the Simini Protect Lavage removed 99.98% of bacteria, which lead to a 38% lower infection rate 90 days post-surgery.    These data suggest there is an untapped opportunity for lower infection rates that are difficult to achieve with current approaches alone.

The best answer to this is to look at the video, about half down this webpage: https://simini.com/why-choose-simini   The video is called the Science of Simini.

The products have two activities: (1) antibacterial / antifungal and (2) anti-biofilm (biofilm is bacteria’s natural armor to protect itself from the immune system and other antibacterial agents).

The antibacterial activity occurs through a process of bacteria cell lysis.   Said another way, it is the physical breakdown the membrane (cell wall) of bacteria.  Simply put, when the bacterial membrane is broken, the contents of the cells are no longer viable and the bacteria dies.

The Simini Protect products are indicated for both soft-tissue and orthopedic surgeries.   The products can also be used for trauma, emergency and other procedures in the veterinary clinic.

The Simini Protect products cannot be used in the eyes or inner ear or middle ear.

There is no known resistance to this physical mechanism of action.

Yes.  You can see a comparison of their anti-biofilm activity relative to chlorhexidine and iodine on this webpage: https://simini.com/simini-protect-products 

The inventor identified multiple conditions necessary for bacterial cell lysis.    These conditions could be achieved using existing ingredients in a specific formulation, rather than requiring a newly discovered active ingredient.   

The Simini Protect products employ a formulation of ingredients with a long history of clinical use both in human and animal health.    This patented formulation of ingredients delivers the product’s anti-bacterial, anti-fungal, and anti-biofilm activity.  

The "How to Use" Questions

  1. Has a fragrance (like vinegar): So you know it is present and active.
  2. Needs to be rinsed with an equal volume of saline after a one-minute exposure.
  3. Is hypertonic, so it can cause transient darkening of exposed red blood cells, however, this generally reverses following exposure to normal moisture levels.
  4. Should not be used for procedures in the inner or middle ear, or eyes.

Just prior to suturing, lavage with the Simini Protect Lavage as you would with normal saline.  We recommend about 20-25ml of Simini Protect Lavage for prophylactic use in canines.  Wait one minute, and then rinse with an equal amount of saline or water.    See product label for full details.

The wound area should be cleaned first and then the Simini Gel can be applied liberally once per day.  The area can be bandaged or left uncovered.   See product label for full details. 

The 7.5ml gel tube is sold in that size so that it can be applied in the clinic and then sent home with the pet-owner to apply once daily for a few days.  The two additional practical benefits of this are: (i) the Simini Protect Gel creates a sustained barrier to inhibit bacteria migration or growth, and (ii) it gives the pet-owner a “job” to do, and insures they keep an eye on the wound (so they best monitor the wound and can let you know sooner if attention is required).

Wounds are most susceptible to bacteria migration during the first 72 hours.

Many are adopting a “Be Kind to Your Future Self” Simini Protect protocol.

                            Have the Simini Protect products ready for all procedures:

• If there is a complication in the procedure – use it

• If the procedure takes longer than normal – use it

• If the pet-owner would be difficult to manage through an infection – use it

• Or just use it to minimize your infection rate on all procedures

The Research Questions

Yes.   On the webpage: https://simini.com/why-choose-simini , the broad spectrum activity graph (top of the page) shows Simini product activity against resistant strains of Staphylococcus Pseudintermedius (MRSP) and Staphylococcus Aureus (MRSA).

Both products are FDA cleared human medical devices.   They have completed all the necessary safety testing in multiple species to achieve human medical device product clearance.  

These products have been evaluated in laboratory tests (in vitro), biofilm tests (in the presence of bacteria’s natural amour), animal models (in-vivo studies) and human clinical studies.    

Yes.  The Simini Protect Lavage has passed standard corrosion testing against common implant materials.

The "How to Order" Questions

Go to www.ordersimini.com    You will require a password to enter the site.  To get a password, email cd@simini.com and we will send you one.    Only veterinarians and clinics can order Simini Protect products.

Visa, Mastercard, Amex, Google Pay, Apple Pay, PayPal

And yes, you can just order it directly from us and we’ll bill you.     Call us at 1-647-292-4920.

Yes.  Email us at cd@simini.com or call 1-647-292-4920.